Somnath Mukherjee, Dionne H Griffin, James R Horn, Shahir S Rizk, Malgorzata Nocula-Lugowska, Magnus Malmqvist, Sangwoo S Kim, and Anthony A Kossiakoff (2018)
Engineered synthetic antibodies as probes to quantify the energetic contributions of ligand binding to conformational changes in proteins
Journal of Biological Chemistry, in press
Travis R. Helgren, Congling Chen, Phumvadee Wangtrakuldee, Thomas E. Edwards, Bart L. Staker, Jan Abendroth, Banumathi Sankaran, Nicole A. Housley, Peter J. Myler, Jonathon P. Audia, James R. Horn, and Timothy J. Hagen (2017)
Rickettsia prowazekii methionine aminopeptidase as a promising target for the development of antibacterial agents
Bioorganic & Medicinal Chemistry, 25, p.813–824.
Kaitlynn R. Davenport, Christopher A. Smith, Heike Hofstetter, James R. Horn, Oliver Hofstetter (2016)
Site-directed immobilization of a genetically engineered anti-methotrexate antibody via an enzymatically introduced biotin label significantly increases the binding capacity of immunoaffinity columns
Journal of Chromatography B, 1021: 114–121
Sean W. Fanning, Richard Walter, James R. Horn (2014)
Structural Basis of an Engineered Dual-Specific Antibody: Conformational Diversity Leads to a Hypervariable Loop Metal Binding Site
Protein Engineering Design and Selection 27 (10): 391-397.
Zheng Zhang, Sriram Jakkaraju, Joy Blain, Kenneth Gogol, Lei Zhao, Robert C. Hartley, c, Courtney A. Karlsson, Bart L. Staker, Lance J. Stewart, Peter J. Myler, Michael Clare, Darren W. Begley, James R. Horn, Timothy J. Hagen (2013)
Cytidine derivatives as IspF inhibitors of Burkolderia pseudomallei
Bioorganic and Medicinal Chemistry Letters, 23(24),pp 6860–6863
Phumvadee Wangtrakuldee, Matthew S. Byrd, Cristine G. Campos, Michael W. Henderson, Zheng Zhang, Michael Clare, Ali Masoudi, Peter J. Myler, James R. Horn, Peggy A. Cotter, and Timothy J. Hagen (2013)
Discovery of Inhibitors of Burkholderia pseudomallei Methionine Aminopeptidase with Antibacterial Activity
ACS Med. Chem. Lett., 2013, 4 (8), pp 699–703
Sztuba-Solińskaa,J., Fanning, S.W., Horn, J.R., and Bujarski, J.J. (2012)
Mutations in the coat protein-binding cis-acting RNA motifs debilitate RNA recombination of Brome mosaic virus.
Virus Research. 170, 138–149
Murtaugh, M.L., Fanning, S.W., Sharma, T.M., Terry, A.M., and Horn. J.R (2011)
A Combinatorial Histidine Scanning Library Approach to Engineer Highly pH-Dependent Protein Switches
Protein Science. 20 (9), 1619-1631 (Featured Cover Art)
Fanning, S.W. and Horn, J.R. (2011)
An Anti-Hapten Camelid Antibody Reveals a Cryptic Binding Site with Significant Energetic Contributions from a Non-Hypervariable Loop.
Protein Science. 20 (7), 1196–1207. (Featured Cover Art)
Fanning, S.W., Murtaugh, M., and Horn, J.R. (2011)
A Combinatorial Approach to Engineer a Dual-Specific Metal Switch Antibody”
Biochemistry, 50 (23), pp 5093–5095.
Franco, E.J., Sonneson,G.J., DeLegge, T.J., Hofstetter,H, Horn, J.R. and Hofstetter, O. (2010)
Production and characterization of a genetically engineered anti-caffeine camelid antibody and its use in immunoaffinity chromatography
J Chromatography B, 878, 177-186
Sonneson, G.J. and Horn, J.R. (2009)
Hapten Induced Dimerization of a Single-Domain VHH Camelid Antibody
Biochemistry. 48, 6693–6695
Horn, J.R., Sosnick, T.R., and Kossiakoff, A.K. (2009)
Principal determinants leading to transition state formation of a protein-protein complex, orientation trumps side chain interactions.
PNAS. 106, 2559-2564
Rich, R.L., et. al. (2009)
A global benchmark study using affinity-based biosensors
Analytical Biochemistry. 386, 194-216
Horn, J.R., Kraybill, B., Petro, E., Coales, S.J., Hamuro, Y., and Kossiakoff, A.K. (2006)
The role of protein dynamics in increasing binding affinity for an engineered protein-protein interaction established by H/D exchange mass spectrometry
Biochemistry. 45: 8488-8498
Kouadio, J.-L., Horn, J.R., Pal, G., and Kossiakoff, A.K. (2005)
Shotgun Alanine Scanning Shows That Growth Hormone Can Bind Productively to Its Receptor through a Drastically Minimized Interface.
J. Biol. Chem. 280: 25524-25532
Horn, J.R. and Shoichet, B.K. (2004)
Allosteric Inhibition through Core Disruption.
J.Mol.Biol. 336: 1283-91
Horn, J.R., Ramaswamy, S., Murphy, K.P. (2003)
Structure and Energetics of Protein-Protein Interactions: The Role of Conformational Heterogeneity in OMTKY3 Binding to Serine Proteases.\\ J.Mol.Biol. 331: 497-508
Horn, J.R., Brandts, J, and Murphy, K.P. (2002)
Van’t Hoff and Calorimetric Enthalpies II: Effects of Linked Equilibria.
Horn, J.R., Russel, D.J., Lewis, E.A., and Murphy, K.P. (2001)
Van’t Hoff and calorimetric enthalpies from isothermal titration calorimetry: are there significant discrepancies?
Murphy, K.P., Baker, B.M., Edgcomb, S.P, and Horn, J.R. (1999)
Structural Energetics of Serine Protease Inhibition.
Pure Appl. Chem. 71, 1207-1213